Needham, MA May 31, 2006
-- Recent independent scientific research funded by the National CFIDS
Foundation, Inc. (NCF) of Needham, MA provided preliminary confirmation of a
new virus identified in
patients with Chronic Fatigue Syndrome. The Foundation's medical research
dovetails with that completed to date by Cryptic Afflictions, LLC *, a
Dr. Steven J. Robbins, virologist and Chief Executive Officer of Cryptic
Afflictions, LLC has discovered a major neuropathogen identified as an RNA
virus designated as Cryptovirus. Substantial clinical and molecular evidence
indicates that this virus is involved in the development of neurological
disorders that include Chronic Fatigue Syndrome (CFS), also known as Myalgic
Encephalomyelitis (M.E.) by the World Health Organization, Multiple
Sclerosis (M.S.) and Idiopathic Epilepsy of unknown cause.
According to the company, "This previously undetected virus appears to be of
significant importance to researchers looking for a cure to Multiple
Sclerosis and many other neurological illnesses. Antibodies to the newly
discovered virus were found in the cerebrospinal fluid and blood of over 90%
of the patients tested with Multiple Sclerosis. It is believed that this
newly discovered virus may prove to be responsible for a host of
neurological disorders. Tests are currently being prepared for tissue
samples of lesions within the brains of patients with Multiple Sclerosis.
This will be the final round of tests before approaching the FDA for
approval of the diagnostic tests."
Dr. Robbins' evidence includes the presence of virus-specific antibodies in
the serum and cerebrospinal fluid of patients suffering from these
disorders, the ability of the virus to cause virtually identical disease in
experimentally-infected animals, and nucleotide sequence data that indicates
that the virus is pandemic and represents a single virus species much like
A recently published medical journal article suggests that Cryptovirus is
most similiar to Parainfluenza Virus 5, a rubulavirus in the paramyxovirus
family. Another rubulavirus related to Cryptovirus and Parainfluenza Virus
5, that has gained national attention for its large outbreak, is the mumps
virus. Rubulavirus infections have been associated with encephalitis,
meningitis, orchitis, inflammation of the testicles or ovaries, spontaneous
abortion, and deafness.
The NCF has conducted its own preliminary research into the potential role
of Cryptovirus and Parainfluenza Virus 5 in Chronic Fatigue Syndrome.
Professor Alan Cocchetto, Medical Director for the Foundation stated, "Our
own funded research first confirmed the lack of a vital protein, known as
Stat-1, in the blood of patients with Chronic Fatigue Syndrome. Stat-1 plays
an indispensable role in immunity. Without this protein, patients are unable
to effectively fight viral and bacterial infections. Thus, the next logical
question to be answered was 'Could a virus be causing this Stat-1
depletion?' " Cocchetto continued, "Parainfluenza Virus 5 is a virus that
had to be seriously considered as a possible piece of this medical puzzle
because it directly targets and destroys the Stat-1 protein." Gail Kansky,
President of the NCF stated, "Once we determined the status of Stat-1 in
patient blood samples, we knew that we had to look for possible evidence of
Parainfluenza Virus 5 infection. It was during this phase of our own
research that we actually learned of Dr. Steven Robbins' discovery of
Cryptovirus specific antibody reactivity in patients with CFS." Dr. Robbins
had tested fifty-six serum specimens from patients who had been diagnosed
with CFS along with eleven matching cerebrospinal fluid samples obtained
from physicians in Brisbane and Southeast Queensland. Dr. Robbins had
determined that 96% of the blood samples and 91% of the spinal fluid samples
tested positively for Cryptovirus specific antibodies in these CFS patients.
The National CFIDS Foundation's own research began to dovetail with that of
Dr. Robbins. Scientists funded by the Foundation performed numerous tests
for Parainfluenza Virus 5 that included antibody as well as PCR specific
probes. Antibody testing provided some initial hints, however a PCR specific
probe picked up the infection in a former patient of David S. Bell, M.D. and
Paul R. Cheney, Ph.D., M.D., both considered well known specialists in the
field of Chronic Fatigue Syndrome. Kansky commented, "Though our funded
research continues in diagnostic testing, our findings have served to
highlight the important work of Dr. Robbins and the role of Cryptovirus and
Parainfluenza Virus 5 infection in CFS."
NCF scientists utilized the NIH Genbank database to find the nucleotide
sequence for a specific viral protein of Cryptovirus that matched 100% to
the porcine (swine) strain of Parainfluenza Virus 5 known as the SER strain.
In 1994, scientists at Bayer AG in Germany first isolated the SER strain
from swine with Porcine Reproductive and Respiratory Syndrome. "This
may represent a zoonotic process since zoonotic viruses are those that can
be transmitted between animals and people" stated Cocchetto. Kansky
commented, "Here we have what appears to be the same viral strain of
Parainfluenza Virus 5 on two continents and in two different populations,
swine and humans. Given that the NCF found Parainfluenza Virus 5 in one CFS
patient in the United States certainly raises the bar." The Foundation is
currently funding further research.
The National Institutes of Health (NIH) has several ongoing grants in the
Parainfluenza Virus 5 field. Currently, however, there is only one U.S.
scientist specifically funded for research on the SER strain of
Parainfluenza Virus 5 by the NIH.
Founded in 1997, the National CFIDS Foundation has grown to
become the largest, all-volunteer patient organization of its type in the
United States. The Foundation has no paid employees and is funded solely by
individual donations for the primary purpose to fund medical research into
the cause and treatment and/or cure of Chronic Fatigue Immune Dysfunction
* "Limina Biotechnologies, Inc. is a recently formed subsidiary of Global
Technologies, Inc. that was established for the purpose of merging Cryptic
Afflictions LLC and
Global Medical Technologies, Inc. It is the intent of management to spin off
this newly formed
corporation once the merger is completed so Limina can raise capital through
its own IPO,"
according to the company's website,
For more information on this finding, including a detailed report on how
these discoveries were made, as well as all supporting source documentation,